BioClosures
BioClosure Container Closure Systems
AdvantaPure BioClosure Container Closure Systems are precision-molded, single-use closures designed for secure, sterile fluid handling in biopharmaceutical processes. Manufactured in ISO-certified cleanrooms from platinum-cured AdvantaSil silicone and TPE AdvantaFlex materials. Fully tested for biocompatibility and extractables, these closures deliver consistent quality and performance.
By eliminating the gaps and irregular surfaces, molded BioClosure systems create a smooth, continuous contact surface that reduces contamination risks and ensures a reliable, leak-free seal. They are compatible with bottles, flasks, and carboys, and can be configured with dip tubes, vent filters, and pre-attached AdvantaFlex or AdvantaSil tubing to support a wide range of closed-system applications. Engineered for autoclave or gamma sterilization, BioClosure systems combine purity, compliance, and reliability to protect the integrity of critical fluid handling workflows.
BioClosure System Assemblies
AdvantaPure BioClosure System Assemblies are single-use, pre-molded, and pre-assembled container closures designed for clean and efficient fluid handling in pharmaceutical and biopharmaceutical environments. Produced in ISO-certified cleanrooms, these assemblies minimize installation time, eliminate cleaning validation steps, and reduce cross-contamination risk.
Available in standard configurations for media bottles, Erlenmeyer flasks, and carboys, BioClosure System Assemblies can include pre-installed AdvantaFlex TPE or AdvantaSil silicone tubing, vent filters, and caps. These assemblies provide a fully closed, sterile pathway ideal for aseptic sampling, media fill, and process development—offering a streamlined, ready-to-use solution that enhances process control and efficiency.
- BioClosure Container Closure Systems
- BioClosure Sterile Media Bottle Assemblies
- BioClosure Sterile Erlenmeyer Flask Assemblies
- BioClosure Cap Assemblies for Carboys
AdvantaSil Silicone Bottle Stoppers
AdvantaPure Silicone Stoppers are precision-molded from platinum-cured AdvantaSil silicone to provide a secure, contamination-resistant seal for bottles and containers used in critical fluid handling. Available in standard sizes 2 through 12, they can be pre-assembled with AdvantaSil silicone or AdvantaFlex TPE tubing to speed setup and reduce labor demands.
Designed specifically for single-use systems, these stoppers help prevent cross-contamination, eliminate cleaning and revalidation requirements, and ensure a reliable, leak-free seal. Their molded design offers consistent fit and performance, while integrated tubing options support faster implementation and stable operation in aseptic processes.